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A novel type of influenza A virus-derived Defective interfering Particle for antiviral therapy

Ref.-Nr.: 1402-5459-BC

Research Tools : Antibodies

Human influenza A virus (IAV) is responsible for seasonal disease in people and can cause worldwide pandemics. The main lines of defense against IAV are vaccines and antiviral drugs.

Influenza vaccines, including killed and live vaccines, recombinant virus-like particles and viral particles, have been available commercially for many years. Typically, the composition of influenza vaccines is based on the major influenza virus strains causing infection in the previous season. Accordingly, ...

Do you need to shut down protein synthesis reversibly and in a cell-type specific manner?

Ref.-Nr.: 0602-5504-LI

Processes and Methods (incl. Screening) : Life Sciences-HTS/HCS
Research Tools : Other
Nucleic Acid-, Protein and Cell-related Technologies : Nucleic acid related

A precise and genetically encoded inhibitor for cell-type selective, inducible and reversible inhibition of protein synthesis

N-substituted pyridiniophosphines, processes for their preparation and their use

Ref.-Nr.: 0042-4938-LC-WA

Processes and Methods (incl. Screening) : Chemical
Research Tools : Other
New Materials

We offer a new family of cationic ligands, namely N-alkyl/aryl pyridiniophosphines. The ligands can be synthesized through a short, scalable, and highly modular route.

Evaluation of their electronic properties evidenced weak σ-donor and quite strong π-acceptor character when used as ancillary ligands.

Novel Biomarkers for Ageing and Metabolic Health

Ref.-Nr.: 1013-5354-MSG

Analytics
Medicine : Therapeutics
Medicine : Diagnostics
Research Tools : Other
Nucleic Acid-, Protein and Cell-related Technologies : Cell related

Biomarkers of ageing have long been sought after to help assess the biological age and general health status of individuals. Considerable efforts have been invested to identify such biomarkers, including physiologic readouts, metabolic parameters, glycomic profiles and others. Nevertheless, markers with strong predictive power have remained elusive.

Work in model organisms has identified several conserved signaling pathways that extend life span, such as reduced insulin/IGF signaling and ...

RNA-CASing: means and methods for selective isolation and stabilization of RNA molecules

Ref.-Nr.: 0706-5433-MSG

Processes and Methods (incl. Screening) : Life Sciences-HTS/HCS
Research Tools : Other
Nucleic Acid-, Protein and Cell-related Technologies : Nucleic acid related

RNACasing: A novel and selective way of isolating and stabilizing RNA molecules, which enables processing, storing and shipping of RNA at room temperature.

SUMOvera: A Truly Orthogonal Cleavage Module

Ref.-Nr.: 0402-5439-LI

Processes and Methods (incl. Screening) : Life Sciences-HTS/HCS
Research Tools : Other
Nucleic Acid-, Protein and Cell-related Technologies : Protein related

SUMOvera enables versatile purification strategies for broad applications in eukaryotic hosts.

Thioimidazolium ionic liquids as non-volatile and derivatizable alkylating reagents

Ref.-Nr.: 0401-5411-LC-WA

Processes and Methods (incl. Screening) : Chemical
Research Tools : Other
New Materials

The offered thioimidazolium ionic liquids are a class of easily synthesized and harnessed alkylating agents that are completely non-volatile. The active alkylating species is produced in-situ, thus eliminating exposure and the need for specialized equipment. These features can also be used in the solid-state by their attachment to a poly(styrene) support, which allows for easy purification of the product and regeneration of the thioimidazolium alkylator and could be of special interest for flow ...