Processes and Methods (incl. Screening)

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A high-throughput compatible workflow for generation and analysis of homogenous human neural microtissues

Ref.-Nr.: 1012-5677-LI

Processes and Methods (incl. Screening)

File no.: MI-1012-5677-LI-ZE
(liked to MI-1012-4430-LI-ZE describing the generation of neuro- epithelial stem cells as precursors for microtissue generation)

A robust method for producing and analyzing highly homogenous human neural organoids.

A novel strategy for reducing inflammation by modulating immune cell metabolism

Ref.-Nr.: 0106-5185-MG

Processes and Methods (incl. Screening) : Life Sciences-HTS/HCS
Medicine : Therapeutics
Nucleic Acid-, Protein and Cell-related Technologies : Cell related

Remodeling the morphology of mitochondria to manipulate immune cell metabolism and hence reduce immune cell activation and effector functions

A predictive 3D multi-scale model of bile flux in the liver lobe

Ref.-Nr.: 1305-5341-MSG

IT / Software / Bioinformatics : Bioinformatics
Processes and Methods (incl. Screening) : Life Sciences-HTS/HCS
Medicine
Nucleic Acid-, Protein and Cell-related Technologies : Cell related

Cholestatic liver diseases are a heterogeneous group of disorders resulting from genetic, metabolic and congenital defects, as well as DILI (drug-induced liver injury, a leading cause of attrition during drug development).

Current diagnostic techniques for DILI and cholestasis are based on the detection of serum markers and imaging methods such as computer tomography. However, these have a low resolution and only provide a limited understanding of the underlying disease etiology. Therapeutic ...

Chlamydomonas Strains that Efficiently Express Nuclear Transgenes

Ref.-Nr.: 0402-3923-MG

Processes and Methods (incl. Screening)

Unicellular eukaryotic green algae from the Chlamydomonas genus are highly attractive for biotechnological production due to their rapid growth and the capability to produce high amounts of biomass at low costs. However, low expression levels of nuclear transgenes in algae have seriously limited the use of algae in production of e.g. “green chemicals”, biofuels or recombinant proteins.

Do you need to shut down protein synthesis reversibly and in a cell-type specific manner?

Ref.-Nr.: 0602-5504-LI

Processes and Methods (incl. Screening) : Life Sciences-HTS/HCS
Research Tools : Other
Nucleic Acid-, Protein and Cell-related Technologies : Nucleic acid related

A precise and genetically encoded inhibitor for cell-type selective, inducible and reversible inhibition of protein synthesis

High-precision base editors for site-specific single nucleotide conversion

Ref.-Nr.: 0402-5782-MG-ZE

Processes and Methods (incl. Screening)

The CRISPR-Cas system is a powerful tool for site-specific genome editing. The Cas9endonuclease is capable of introducing DNA double strand breaks at a desired location withhigh precision. The lesion is repaired either in an errorprone process leading to gene inactivation or in a highly accurate way relying on an external template. Modification of the template may serve to introduce selected mutations, modified sequencesorentirely new genes.The accurate pathway comes with low endogenous efficiency. ...

N-substituted pyridiniophosphines, processes for their preparation and their use

Ref.-Nr.: 0042-4938-LC-WA

Processes and Methods (incl. Screening) : Chemical
Research Tools : Other
New Materials

We offer a new family of cationic ligands, namely N-alkyl/aryl pyridiniophosphines. The ligands can be synthesized through a short, scalable, and highly modular route.

Evaluation of their electronic properties evidenced weak σ-donor and quite strong π-acceptor character when used as ancillary ligands.

Neuro-epithelial stem cells (NESC) capable of forming both central nervous system (CNS) and peripheral nervous system (PNS) neurons

Ref.-Nr.: 1012-4430-LI

Processes and Methods (incl. Screening)

File no.: MI-1012-4430-LI-ZE
(liked to MI-1012-5677-LI-ZE describing the generation of human neural microtissues from NECS cells)

A novel precursor population that forms electrophysiologically functional neurons more quickly than protocols starting with hPSCs.

New KDAC assay and selection system

Ref.-Nr.: 0803-5480-MSG

Analytics
Processes and Methods (incl. Screening) : Life Sciences-HTS/HCS
Medicine : Diagnostics
Nucleic Acid-, Protein and Cell-related Technologies : Protein related

Extremely sensitive, reliable and fast novel KDAC assay, which can be performed in a continuous format. This novel KDAC assay is based on Firefly luciferase harboring an acetylation on an essential active site lysine, incorporated by genetic code expansion. We furthermore offer a bacterial selection system for KDACs, which uses a reporter enzyme inactivated by lysine modifications at an essential active site residue, thereby linking deacetylase activity to a selectable output.

Novel antiviral therapy against HIV-1 and alphaviruses: reducing frameshifting by increasing tRNALeu concentrations

Ref.-Nr.: 0707-5639-MG

Processes and Methods (incl. Screening) : Life Sciences-HTS/HCS
Medicine : Therapeutics
Nucleic Acid-, Protein and Cell-related Technologies : Nucleic acid related

Antiviral therapy against retroviruses and alphaviruses using tRNALeu(UUA) overexpression

RNA-CASing: means and methods for selective isolation and stabilization of RNA molecules

Ref.-Nr.: 0706-5433-MSG

Processes and Methods (incl. Screening) : Life Sciences-HTS/HCS
Research Tools : Other
Nucleic Acid-, Protein and Cell-related Technologies : Nucleic acid related

RNACasing: A novel and selective way of isolating and stabilizing RNA molecules, which enables processing, storing and shipping of RNA at room temperature.

SUMOvera: A Truly Orthogonal Cleavage Module

Ref.-Nr.: 0402-5439-LI

Processes and Methods (incl. Screening) : Life Sciences-HTS/HCS
Research Tools : Other
Nucleic Acid-, Protein and Cell-related Technologies : Protein related

SUMOvera enables versatile purification strategies for broad applications in eukaryotic hosts.

Thioimidazolium ionic liquids as non-volatile and derivatizable alkylating reagents

Ref.-Nr.: 0401-5411-LC-WA

Processes and Methods (incl. Screening) : Chemical
Research Tools : Other
New Materials

The offered thioimidazolium ionic liquids are a class of easily synthesized and harnessed alkylating agents that are completely non-volatile. The active alkylating species is produced in-situ, thus eliminating exposure and the need for specialized equipment. These features can also be used in the solid-state by their attachment to a poly(styrene) support, which allows for easy purification of the product and regeneration of the thioimidazolium alkylator and could be of special interest for flow ...