Imaging and Microscopy

Cell-Penetrating Fluorescent Dyes with Secondary Alcohol Functionalities

Ref.-No.: 0707-5236-BC

Imaging and Microscopy
New Materials

Fluorescent dyes are widely used as indispensable markers in biology, optical microscopy, and analytical chemistry. The availability and the proper choice of the dye is a key factor to success of the entire labelling and imaging procedure. Due to superior brightness and photostability, synthetic dyes often represent an attractive alternative to fluorescent proteins.

Among the multitude of fluorophores reported so far, only rhodamines, carbopyronines, and silicon-rhodamines bearing a carboxyl ...

Flash 2 – Real-Time Magnetic Resonance Imaging (MRI)

Ref.-Nr.: 0707-4198-BC

Imaging and Microscopy
Sensors, Devices and Components

Magnetic resonance imaging (MRI) is nowadays a leading mo¬dality for diagnostic imaging with about 100 million examinations per year worldwide. However, when invented by Paul Christian Lauterbur in 1973, MRI was too slow to allow for routine medical applications. A breakthrough was achieved in 1985 by the FLASH (Fast Low Angle Shot) technique developed by Jens Frahm and his team at the Max-Planck-Institute for Biophysical Chemistry in Göttingen, Germany. With FLASH the measuring time for a cross-sectional ...

Multichannel coil for UHF MRI

Ref.-No.: 0107-4677-BC

Imaging and Microscopy
Sensors, Devices and Components

Exploiting the benefits offered by magnetic resonance imaging (MRI) at ultra-high fields (≥ 7 Tesla) requires optimized radiofrequency (RF) coils. MRI at UHF operates in a regime where the RF wavelength is comparable to the dimensions of the sample size, resulting in an inhomogeneous distribution of the transmit field (B₁⁺) and in an impaired image quality. An array of independent transmit coils arranged in multiple rows provides the degrees of freedom to influence the ...

Nanographene-based dyes as high performance probes for super-resolution microscopy

Ref.-Nr.: 0903-5658-LC; 0903-5696-LC; 0903-5692-LC

Analytics
Imaging and Microscopy
New Materials

Super-resolution microscopy critically relies on the availability of appropriate fluorophores. For single-molecule localization microscopy (SMLM), fluorophores are needed that stochastically switch between bright (on) and dark (off) states. This phenomenon is also called fluorescence blinking. For stimulated emission depletion microscopy (STED) the dyes must be photo-switchable.