Technology Offers

File no.: MI-1012-5677-LI-ZE
(liked to MI-1012-4430-LI-ZE describing the generation of neuro- epithelial stem cells as precursors for microtissue generation)

A robust method for producing and analyzing highly homogenous human neural organoids.

With approximately 600,000 deaths annually colorectal cancer (CRC) is one of the most common cancer types worldwide. Early cancer and pre-cancer (polyps) detection by colonoscopy over the age of 50 until now is the best strategy for disease control and the chance of the cancer to be curable. Epigenetic changes such as DNA methylation has been shown to occur already at early stages of tumor development making such differentially methylated regions (DMRs) highly attractive for biomarker development ...

Remodeling the morphology of mitochondria to manipulate immune cell metabolism and hence reduce immune cell activation and effector functions

Cholestatic liver diseases are a heterogeneous group of disorders resulting from genetic, metabolic and congenital defects, as well as DILI (drug-induced liver injury, a leading cause of attrition during drug development).

Current diagnostic techniques for DILI and cholestasis are based on the detection of serum markers and imaging methods such as computer tomography. However, these have a low resolution and only provide a limited understanding of the underlying disease etiology. Therapeutic ...

In contrast to target-based drug discovery, phenotypic screening discloses the effect of a compound on a biological system without revealing its mode of action or its interaction sites. Phenotypic screening has delivered several new valuable drugs, however, the major challenge remains target deconvolution (1). In recent years, “omics” techniques and bioinformatics have brought significant advances to target identification in drug discovery phenotypic screening. However, such analyses can become ...

The study of mechanical properties of materials at high temperatures at the microstructural length scale requires dedicated testing setups. An accurate measurement of the sample temperature is vital for reliable testing. Most of the successful current testing platforms record the temperatures of the sample and tip near the heating sources but not at the respective surface. As a consequence, due to spatial and temporal thermal gradients a reliable surface temperature cannot be measured today. Even ...

The dynamics of complex flows and turbulences are dominated by vortices of many different scales. In general, the vortex describes the group motion of fluid elements in a circular fashion, whereas the vorticity quantizes this spinning moment of a fluid element confined to a small neighborhood.

For diagnosis of flows, conventional techniques track the movements of small particles added into the flow (e.g., Lagrangian particle tracking, LPT, and particle image velocimetry, PIV). However, ...

Anti-IgG secondary antibodies are major tools for the detection or immobilization of primary antibodies in approaches such as western blotting, ELISA, Co-IP and immunofluorescence. Polyclonal anti-IgG secondary antibodies are produced in animals, such as mouse, rabbit, rat, and goat and are directed against the IgG classes of these animals. Thus, the generation of such secondary antibodies requires the keeping and use of a large number of animals, which is not only costly but also a major ethical ...

Ultrasound is being used in many fields ranging from medical imaging and therapy to non-destructive testing, contact-free particle handling or spatially selective heating in industrial settings. Often, those applications require shaping (including focusing) of an ultrasonic field. Compared to existing transducers with fixed lenses or phased array transducers (PATs) the present invention allows much more sophisticated sound fields to be generated using much simpler and cheaper technology.

PC-based software to construct lattice sections and clusters/molecules with extended graphical display and analysis options.

Fluorescent dyes are widely used as indispensable markers in biology, optical microscopy, and analytical chemistry. The availability and the proper choice of the dye is a key factor to success of the entire labelling and imaging procedure. Due to superior brightness and photostability, synthetic dyes often represent an attractive alternative to fluorescent proteins.

Among the multitude of fluorophores reported so far, only rhodamines, carbopyronines, and silicon-rhodamines bearing a carboxyl ...

Evaporation cells for thin film deposition often operate under ultrahigh vacuum or special gas atmosphere, requiring long growth campaigns and short maintenance openings to preserve the best possible vacuum environment. The deposition leads to coating of the inner chamber walls, the removal of which is difficult and very time consuming. Growth control and interruptions during material deposition may require frequent operation of the closure device or shutter. The commonly used shutter (Fig. 1) ...

This novel screwless coupling, which can also be used as overload clutch, offers the possibility without additional tools to connect two rotatable elements even under extremely tight conditions, backlash-free and force fit with high precision. Due to their size, couplings known to date on the market are unsuitable for applications in the field of electronics, optics, metrology and precision engineering. Whereas thanks to the new technology, which was developed at the Max Planck Institute for Solar ...

Lock-in thermography (LIT) is a versatile and very sensitive tool to detect local heat sources in electronic components by 2d-images oft he sample. The DECONV program is a tool for converting these lock-in thermography images into local power density images or simulating LIT images by performing mathematical deconvolution or convolution and uses input image data in ASCII table form. Results are exported as ASCII tables or as bmp-files.

This software is a further development of an older ...

A precise and genetically encoded inhibitor for cell-type selective, inducible and reversible inhibition of protein synthesis

The CRISPR-Cas system is a powerful tool for site-specific genome editing. The Cas9endonuclease is capable of introducing DNA double strand breaks at a desired location withhigh precision. The lesion is repaired either in an errorprone process leading to gene inactivation or in a highly accurate way relying on an external template. Modification of the template may serve to introduce selected mutations, modified sequencesorentirely new genes.The accurate pathway comes with low endogenous efficiency. ...

Screening the level of specific blumenols in plant leaves allows simple implementation in marker assisted breeding and high-throughput analysis.

An efficient system to monitor and control animal behavior in wildlife as well as in laboratory settings

Super-resolution microscopy critically relies on the availability of appropriate fluorophores. For single-molecule localization microscopy (SMLM), fluorophores are needed that stochastically switch between bright (on) and dark (off) states. This phenomenon is also called fluorescence blinking. For stimulated emission depletion microscopy (STED) the dyes must be photo-switchable.

Extremely sensitive, reliable and fast novel KDAC assay, which can be performed in a continuous format. This novel KDAC assay is based on Firefly luciferase harboring an acetylation on an essential active site lysine, incorporated by genetic code expansion. We furthermore offer a bacterial selection system for KDACs, which uses a reporter enzyme inactivated by lysine modifications at an essential active site residue, thereby linking deacetylase activity to a selectable output.

Antiviral therapy against retroviruses and alphaviruses using tRNA^Leu(UUA) overexpression

Synthetic Glycosylphosphatidylinositols (GPIs) with high selectivity and purity for Toxoplasmosis diagnosis and vaccine.

Researchers of the Max-Planck-Institute for Colloids and Interfaces and the Paul-Ehrlich-Institute (PEI) have developed a novel codon-specific elongation model (COSEM), that is based on the question how codon bias affects protein expression in combination with a deep understanding of protein synthesis.

Speckle interferometry is an established metrology technique for the characterization of rough objects. Deformations of rough objects under a load can be determined, as well as – with the help of an additional second wavelength – the surface shape of the object under test. As an illustration, Figure 1 (left) shows the so called raw phase as a result of a deformation measurement on a metal plate. The shape and the density of the fringes indicate the response of the metal plate to the load.
Owing ...

SIMNRA is a Microsoft Windows program for the simulation of energy spectra for ion beam analysis with incident ions from about 100 keV to many MeV. SIMNRA can be used for the simulation of Rutherford backscattering (RBS), elastic backscattering with non-Rutherford cross-sections (EBS), nuclear reaction analysis (NRA), elastic recoil detection analysis (ERDA), and medium energy ion scattering (MEIS). Almost 3000 different non-Rutherford and nuclear reactions cross-sections for incident protons, ...

Im Zuge der stetigen Weiterentwicklung und Nachfrage auf dem Gebiet der minimal invasiven Chirugie wurde am Max-Planck-Institut für intelligente Systeme in Stuttgart im Team von Herrn Prof Sitti für patientenfreundliche Magen-Darm-Untersuchungen ein kabelloses kapselförmiges Endoskop in Pillengröße, das sogenannte "B-MASCE" entwickelt. Die aus einem Elastomer bestehende Kapsel dient hierbei sowohl als Gehäuse als auch als Federelement für die Nadel. Über in der Kapsel eingebaute Magnete ...

SUMOvera enables versatile purification strategies for broad applications in eukaryotic hosts.

The presented technology offers an enhanced streaming rendering pipeline that enables the display of high fidelity, high framerate and high solution for noval views in real time on thin lightweight HMDs suitable especially for VR experiences.

How does it work?

The key idea of this technology is based on a novel algorithm for Potentially Visible Set (PVS) creation: the camera offset space (COS), which for a given point on the image plane provides information under which camera ...